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KMID : 0365819750150010309
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Journal of Pusan Medical College
1975 Volume.15 No. 1 p.309 ~ p.315
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Effect of Tetracycline on the Potassium Permeability of the Rabbit Erythrocyte Membrane
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Abstract
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The effects of tetracycline on the potassium permeability of the rabbit erythrocyte membrane are investigated and the results are summarized as follows.
1. Tetracycline causes the efflux of K+ across the rabbit erythrocyte membrane. The osmotic resistance of tetracycline-treated erythrocytes is diminished. This diminution of the osmotic resistance is more pronounced by increasing concentration of tetracycline and longer incubation time.
2. Cysteine and glutathione have little influence on the diminution of osmotic resistance induced by tetracycline.
3. The addition of PCMB and DNFB augments K outflux slightly while EDTA and EGTA have no effect on the increase in K outflux by tetracycline.
4. Tetracycline inhibits Na+-K+ ATPase activity of ghosts cells of the rabbit. The inhibition of Na´-K´ ATPase activity by tetracycline is not prevented by an addition of cysteine in the incubation medium.
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